Quoted from: http://www.feldgrau.com/InfDiv.php?ID=163
Beginning:
The 250.Infanterie-Division was formed in Spain during the last week of June 1941, immediately after the German attack on the Soviet Union. The unit was an offical Spanish sponsered formation created to partially repay the debt owed Germany for its vitally important assistance during the Spanish Civil War during 1936-1939. It was formed with Spanish volunteers from across Spain who flocked en masse to serve in the unit, originally named simply the Spanish Division of Volunteers, or more properly, Division Espanola de Voluntarios (DEV). The division was exclusively a foreign volunteer unit, designed for service within the German Wehrmacht, but to consist soley of Spaniards and to be led soley by Spanish officers.
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Ending:
Finally, on October 5th and 6th, 1943, the division was ordered to fall back from its positions. Between October 6th and 12th, 1943, the division was relieved by the 81.Infanterie-Division and the 123.Infanterie-Division. The division was transfered to the region of Volosovo where soon after it was ordered to return to Spain, leaving in its place the Spanish Legion, a battalion-sized unit consisting of about 1,500 Spanish troops that choose not to return to Spain but to instead continue fighting the Soviets. The first troops began to arrive back in Spain on October 29th, 1943. The division had seen nearly 50,000 men serve within its ranks over the period of more than two years at or near the front, and 12,726 men had become casualties while in its service.
Also check: http://www.feldgrau.com/spain.html